MVP Immunohistochemistry is a Useful Adjunct in Distinguishing Leiomyosarcoma from Leiomyoma and Leiomyoma with Bizarre Nuclei

Morphologically, distinguishing between leiomyoma (LM) and leiomyosarcoma (LMS) is not always straightforward, especially with benign variants such as bizarre leiomyoma (BLM). To identify potential markers of malignancy in uterine smooth muscle tumors, proteomic studies were performed followed by assessment of protein expression by immunohistochemistry. Archival formalin-fixed paraffin-embedded (FFPE) tissues from tumors (n=23) diagnosed as LM, BLM and LMS (using published criteria) were selected for the study.

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