CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency

Ding and colleagues demonstrate that induced pluripotency can be achieved through targeted activation of endogenous Oct4 or Sox2 genes. With CRISPR activation, the promoter and enhancer are specifically remodeled, Oct4 or Sox2 is derepressed in fibroblasts, and reprogramming is triggered toward pluripotency.

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