Potential Visualization of Sorafenib-Induced Acidosis Using 11C-Acetate PET/CT in Patients With Hepatocellular Carcinoma

Abstract 11C-acetate uptake could be increased in physiologic or inflammatory conditions without evidence of cancer. We report a hepatocellular carcinoma patient with sorafenib-induced metabolic acidosis, who showed increased hepatic uptake of 11C-acetate. 11C-acetate PET/CT might be a potentially useful surrogate marker to monitor these adverse effects via the changes in 11C-acetate uptake patterns from before to after drug withdrawal.

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