Evaluation of lipid-lowering effect of Cynara scolymus extract-loaded mesoporous silica nanoparticles on ultra-lipid-fed mice

Abstract

In current investigation, twenty mice were divided into 4 different equal groups as follows: group CS which received 0.1 ml Cynara scolymus extract (diluted in distilled water) at dose of 600 mg kg⁻¹ daily for 3 weeks, group A which received 0.1 ml Atorvastatin 40 (diluted in distilled water) at dose of 20 mg kg⁻¹ daily for 21 days, group T which received 0.1 ml of Cynara scolymus extract at dose of 600 mg kg⁻¹ daily in nonporous (diluted in distilled water) during experimental period, and control group (group C) which received the same volume of normal saline. The supplements were gavaged in all animals, during experiment period, and blood samples were obtained after 21 days. Results showed that total cholesterol and triglyceride decreased significantly in the treatment group compared with the control and CS groups (p < 0.05). It seems that mesoporous silica nanoparticles improve drug delivery and therefore Cynara scolymus extract-loaded mesoporous silica nanoparticles has more effective lipid-lowering action than Cynara scolymus extract.

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