Normal tissue complication probability (NTCP) modelling of pulmonary toxicity after stereotactic and hypo-fractionated radiotherapy for central lung tumors

We scored grade ≥3 clinical and radiographic bronchial toxicity in patients with central lung tumors treated using ≤12 fractions. All analyzed dosimetric parameters were significantly correlated with clinical and lobar bronchial radiographic toxicity, and V130Gy,EQD had the highest odds ratio for both. NTCP modelling showed a volume dependency for both toxicities. On multivariate analyses, significant predictors for clinical toxicity were a planning target volume overlapping the trachea/main stem bronchus, COPD, and the total V130Gy,EQD.

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