Difficulties in pain management using oxycodone and fentanyl in enzalutamide-treated patients with advanced prostate cancer

Pain treatment in patients with bone metastasized advanced prostate cancer is often challenging. A range of treatment modalities are available to control prostate cancer-specific pain, such as androgen deprivation therapies, taxane-based chemotherapy, radionuclide therapy with radium-223 or palliative radiotherapy. In addition, analgesics are commonly used for direct symptom management.

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