A Multicenter Study of Carbon-ion Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck: Sub-analysis of the Japan Carbon-ion Radiation Oncology Study Group (J-CROS) Study (1402 HN)

Adenoid cystic carcinomas of the head and neck are rare, comparatively radioresistant tumors. In this large cohort of a retrospective multicenter study, we evaluated the effectiveness and safety of carbon-ion radiotherapy in 289 patients with adenoid cystic carcinoma of the head and neck. The physical and biological characteristics of carbon-ions allowed delivery of localized high tumor doses, resulting in good local control and overall survival with tolerable treatment-related toxicity.

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