Urinalysis of MMX-mesalazine as a tool to monitor 5-ASA adherence in daily IBD practice

Summary

Adherence is pivotal but challenging in ulcerative colitis (UC) treatment. Many methods to assess adherence are subjective or have limitations. (Nac-)5-aminosalicylic acid (5-ASA) urinalysis by High-Performance Liquid Chromatography (HPLC) seems feasible and reproducible in healthy volunteers. We performed a prospective study in adult quiescent UC patients to evaluate the feasibility of spot (Nac-)5-ASA urinalysis by HPLC to assess adherence in daily IBD care. Twenty-nine patients (51.7% male, mean age 52 ± 11 yrs) were included (median FU 9 months) and collected weekly spot urine samples. We found large variation in spot (Nac-)5-ASA urinary excretion that was unrelated to brand, dosing schedule or dosage of 5-ASA. In conclusion spot (Nac-)5-ASA urinalysis is not applicable to assess 5-ASA adherence in daily IBD care.

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