Legumain correlates with neuroblastoma differentiation and can be used in prodrug design

Abstract

Neuroblastoma (NB) is a highly malignant solid tumor in children. The cysteine endopeptidase legumain is expressed in adult solid tumors, but its expression in NB has not been examined. In this study, we assayed legumain expression in two NB cell lines and in microarrays of tumor tissues collected from 46 children with undifferentiated NB, differentiated NB and ganglioneuroblastoma. Correlation analyses showed that legumain was expressed in all NB cell lines tested, and that expression correlated with the degree of tumor differentiation.

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Legumain correlated with neuroblastoma differentiation by detection of clinic tumors EMC-AANL-DOX activated by legumain presented better efficacy and lower toxicity in tumor-bearing models of neuroblastoma.

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