Store-Operated Ca Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming

Clonal expansion of T cells is critical for protective immunity. Vaeth et al. (2017) demonstrate that store-operated calcium entry (SOCE), calcineurin, and NFAT control cell-cycle entry and proliferation of activated T cells through upregulation of glycolysis and oxidative phosphorylation.

http://ift.tt/2wMGiNo