Fatty acid metabolism and prospects for targeted therapy of cancer
Tingting Chen and Hua Li
The levels of fatty acid (FA) de novo synthesis and degradation are elevated in cancer cells. Therefore, targeted inhibition of the key enzymes involved in FA metabolism, such as ATP-citrate lyase (ACLY), acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN), monoacylglycerol lipase (MAGL), and stearoyl-CoA desaturase 1 (SCD1), or utilization of anticancer exogenous FAs might be an effective way for cancer therapy.
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