Everolimus for the Treatment of Tuberous Sclerosis Complex–Related Cardiac Rhabdomyomas in Pediatric Patients

Cardiac rhabdomyoma (cRHM), a benign, smooth-muscle hamartoma, occurs predominantly in infants and children; approximately 75% of affected children are aged ≤1 year, and 33% are aged ≤1 month.1,2 cRHM is the most common type of primary cardiac tumor identified in pediatric patients, accounting for >60% of all primary cardiac tumors in this population,2-4 with an estimated incidence of 0.02%-0.08% of live births.2,5 It is also the most common cardiac tumor of the fetus.2

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