Adaptive Radiation Therapy: Off-Line, On-Line, and In-Line?

In a recent critical review by Lim-Reinders et al (1), published online in the Red Journal, the authors are applauded for tackling an important and relevant critical review about on-line adaptive radiation therapy (ART). The authors provide a rationale for ART, differentiate between on-line and off-line approaches, and review the concepts and challenges associated with the various workflow procedures underlying on-line ART. They present examples of how different on-line approaches have been implemented at various treatment centers, and they also summarize the literature relevant to the application of on-line ART for different treatment sites.

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