Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations

Keller, Protze, and colleagues show that atrial and ventricular cardiomyocytes develop from distinct mesoderm populations. Molecular and functional analyses revealed that appropriate mesoderm patterning is required for generating enriched populations of atrial or ventricular cardiomyocytes from hPSCs. These findings provide important new insights for the derivation of populations for future therapeutic applications.

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