Cell Imaging: Spatiotemporally Controllable Peptide-Based Nanoassembly in Single Living Cells for a Biological Self-Portrait (Adv. Mater. 32/2017)

A spatiotemporally-controllable peptide-based nanoassembly in a single living cell, for a biological self-portrait is reported by Xing-Jie Liang and co-workers in article number 1601128. The suitability of the synthesized probe is indicated by rapid cell permeation, sitespecific in situ self-assembly, responsive fluorescence, superior biocompatibility and sensitivity, and robustness, which allows longterm recording and simultaneously evaluating the real-time location and bioactivity. This noninvasive investigation can be further expanded to other bioactive molecules, thus facilitating quantitative imaging in vivo.

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