Sex differences in AngII-Stimulated fluid intake

Abstract

Sex has a clear effect on the renin-angiotensin-aldosterone system. While sex differences in the pressor response to angiotensin II (AngII) are well established, understanding sex differences in the fluid intake response to AngII are clouded by conflicting reports. Here we suggest that accounting for differences in body weights contribute to the discrepancies in the literature. Our recent findings demonstrate that body weight influences AngII-stimulated water intake under certain conditions in males, but not females. When differences in body weights are corrected for under the appropriate circumstances we found that males consume more water in response to AngII compared to females. Males and females also show differences in drinking microstructure, i.e. bottle spout lick patterns, which provides clues into the mechanism(s) underlying this sex difference. Estrogens, which inhibit AngII-stimulated fluid intake and circulate in higher levels in females, likely contribute to this sex difference. This review also discusses the diversity in estrogen signaling via multiple estrogen receptor subtypes which selectively inhibit AngII-stimulated fluid intake.

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