Breast cancer risk after radiotherapy for Hodgkin lymphoma: influence of gonadal hormone exposure

It is unknown whether gonadal hormone exposure affects the risk of radiation-associated breast cancer in female Hodgkin lymphoma survivors. We performed a nested-case control study to assess the separate and joint effects of radiation dose to the breast and hormone exposure on breast cancer risk. Risk increased linearly with radiation dose, decreased with shorter duration of ovarian function, and did not appear to be influenced by hormone use among women with treatment-induced early menopause.

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