Prostaglandin E1-Induced Periostitis and Reversibility with Discontinuation

A 4.1 kg full term infant with a known diagnosis of hypoplastic left heart syndrome was admitted to our pediatric intensive care unit after birth. Prostaglandin E1 (PGE1) infusion at 0.03 μg/kg/min was initiated immediately and continued thereafter for a prolonged period. He was listed for heart transplantation because of persistent poor right ventricle function and significant atrio-ventricular valve regurgitation. He underwent pulmonary arteries band placement to prevent excessive pulmonary blood flow and worsening heart failure.

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