Prevalence of serrated polyposis syndrome in an FIT-based colorectal cancer screening cohort in Italy

To the Editor

We read with interest the recent data reported by IJspeert et al,1 Biswas et al2 and Moreira et al3 whom evaluated the prevalence of serrated polyposis syndrome (SPS), a disease characterised by the development of multiple serrated polyps throughout the colon with an increased risk to develop colorectal cancer (CRC),4 inside CRC screening programmes. A guaiac faecal occult blood test cohort from the UK showed a frequency of SPS ranging from 0.03% to 0.66%.12 Other cohorts based on primary colonoscopy showed a prevalence of SPS between 0.1% and 0.4%.1 The only published data on SPS frequency within faecal immunochemical test (FIT) programmes are from Spain and ranged from 0.34% to 0.8%.13 Since FIT has widely become the method of choice for CRC screening, data from other...

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