Left hemispheric breakdown of LTP-like cortico-cortical plasticity in schizophrenic patients

Schizophrenia is a devastating illness, with a prevalence of 1% (Stephan et al, 2009). It is characterized by positive symptoms (delusions, hallucinations and disorganized thoughts) and negative symptoms such as avolition, alogia, and apathy. An emerging hypothesis is that schizophrenia may be interpreted as a brain disconnection syndrome, with abnormal interactions between widespread brain areas (Ribolsi et al., 2009, Wheeler et al., 2014). Schizophrenia has been associated not only to a local dysfunction of specific brain areas but also with a disruption of communication trough a reduced inter-hemispheric connectivity (Stephan et al., 2009; Chang et al., 2015).

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