The image on the cover is a schematic illustration of how two mutually none exclusive theories: atavism (dating back to the pre-Cambrian period) and somatic evolution/convergent evolution can both contribute to explaining cancer evolution. In article 1700039, Thomas et al. discuss the criteria that should be applied to discriminate between the two competing theories, and propose potential applications of this conceptual framework in developing novel cancer treatment strategies. Original artwork by Eric Pelatan.
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