Getting Drugs Across Biological Barriers

The delivery of drugs to a target site frequently involves crossing biological barriers. The degree and nature of the impediment to flux, as well as the potential approaches to overcoming it, depend on the tissue, the drug, and numerous other factors. Here an overview of approaches that have been taken to crossing biological barriers is presented, with special attention to transdermal drug delivery. Technology and knowledge pertaining to addressing these issues in a variety of organs could have a significant clinical impact.

Biological barriers throughout the body present challenges for drug delivery. Chemical, physical, and biomolecule-mediated approaches to overcoming biological barriers have been developed for a variety of anatomic locations. The mechanisms and applications of these approaches are reviewed.

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