The effect of breast irradiation on cardiac disease in women enrolled on BCIRG-001 at 10 year follow-up

Radiation therapy for breast cancer increases the risk of long term cardiac morbidity, but modern techniques may decrease this risk. This work presents secondary analyses of cardiac outcomes from the control arm of BCIRG-001. We find an increase in arrhythmias but no significant increase in the risk of MI and CHF at 10 years in LN positive women treated with breast RT and uniform adjuvant doxorubicin-based chemotherapy.

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