Clinical usefulness of serum antibodies as biomarkers of gastrointestinal and liver diseases

The progressively growing knowledge of the pathophysiology of a number of immune-mediated gastrointestinal and liver disorders, including autoimmune atrophic gastritis, coeliac disease, autoimmune enteropathy, inflammatory bowel disease, autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cholangitis and autoimmune pancreatitis, together with the improvement of their detection methods have increased the diagnostic power of serum antibodies. In some cases −coeliac disease and autoimmune atrophic gastritis- they have radically changed gastroenterologists' diagnostic ability, while in others −autoimmune hepatitis, inflammatory bowel disease and autoimmune pancreatitis- their diagnostic performance is still inadequate.

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