Polymer Nanoparticles: Synthesis and Assembly of Click-Nucleic-Acid-Containing PEG–PLGA Nanoparticles for DNA Delivery (Adv. Mater. 24/2017)

Co-delivery of both chemotherapy drugs and siRNA from a single delivery vehicle can have a significant impact on cancer therapy. In article number 1700743, Jennifer Cha and co-workers demonstrate that significant amounts of DNA can be encapsulated within poly(lactic-co-glycolic acid) (PLGA)-containing nanoparticles through the use of a new synthetic DNA analog, click nucleic acids (CNAs), demonstrating their potential as carriers for chemotherapy agents and gene silencers.

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