Hodgkin lymphoma classification: Are we at a crossroads?

On the basis of the putative origin from germinal center B cells, the gene expression profile, the expression of the B-cell phenotype, and the propensity to progress toward large B-cell lymphoma, nodular lymphocyte-predominant Hodgkin lymphoma should be classified as a special type of B-cell lymphoma with a follicular center cell origin. To guarantee the appropriate management of patients, information on the nodular growth patterns, the amount of (the number and the size) diffuse areas, and the tumor cell richness should be reported because of the clinical associations of these features.

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