CT radiomics predicts HPV status and local tumor control after definitive radiochemotherapy in head and neck squamous cell carcinoma

This study shows that higher pre-treatment tumor heterogeneity, quantified using radiomics of contrast-enhanced CT imaging, is associated with worse prognosis in head and neck squamous cell carcinoma and the absence of HPV infection. Overall, our analysis provides an evidence that a radiomic signature might be a useful input in risk assessment in addition to clinical parameters (tumor stage, tumor volume and HPV status).

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