Route of ondansetron administration and ventricular arrhythmias

Moeller et al published a large retrospective study that identified children who developed a ventricular tachyarrhythmia within 24 hours of receiving ondansetron.1 Although nearly 200 000 doses of ondansetron were administered in the cohort, only 7 patients experienced a ventricular tachyarrhythmia within 24 hours after ondansetron administration. All 7 patients had a baseline cardiac condition (eg, baseline conduction disorder) with a strong predisposition to arrhythmias. Two of the 7 had received concomitant QT-prolonging medications, and 3 had an electrolyte imbalance.

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