Primary Seminal Vesicle Carcinoma. The Usefulness of Pax8 Immunohistochemical Expression for the Differential Diagnosis

Primary seminal vesicle carcinoma is a rare entity whose diagnosis can be achieved ruling out the main carcinomas that commonly invade the seminal vesicles. Although a panel of immunohistochemical markers (CA125, CK7, CK20, PSA and PSAP) has been proposed as unique for primary seminal vesicle carcinoma, a reliable positive marker is lacking. In this article, we report a case of primary seminal vesicle carcinoma in a 57-years-old man. The tumor was localized to the left seminal vesicle and histologically characterized by papillae lined by broad eosinophilic cells with pleomorphic nuclei.

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