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Κυριακή 29 Οκτωβρίου 2017

Immediately restored full arch-fixed prosthesis on implants placed in both healed and fresh extraction sockets after computer-planned flapless guided surgery. A 3-year follow-up study

Abstract

Background

The treatment of patients by the use of immediate implant placement in post-extractive site is a challenging procedure.

Purpose

A 3-year clinical and radiological study of post-extractive implants placed using flapless guided surgery and immediately functioning.

Materials and Methods

Thirty-two patients (23 females and 9 males), aged between 44 and 73 years (a mean age of 59.5) were treated with immediate full arch restorations and flapless implant surgery in fresh extraction and healed sites. A double-guide technique stent in conjunction with the NobelGuide system (Nobel Biocare AB, Göteborg, Sweden) was used.

Results

A total of 285 implants over 32 patients were assessed. The patients were clinically and radiologically followed for 3 years. One hundred and ninety-five implants were placed in the maxilla and 90 in the mandible. Eight patients received implants in both arches. One hundred and ninety-seven implants were placed in extraction sites (137 maxilla, 60 mandible) and 88 in healed sites (58 maxilla and 30 mandible). The overall cumulative implant survival rate (CISR) was 97.54%. Two implants failed in maxillary healed sites (CISR 96.55%), three in maxillary extraction sites (CISR 97.81%), and two in mandibular extraction sites (CISR 96.66%). No implant failed in healed mandibular sites (CSR 100%). All fixed prostheses maintained stability and good functionality during the follow-up, accounting for a cumulative prosthesis survival rate (CPSR) of 100%. The overall marginal bone level (MBL) was −0.52 mm (SD −0.18) after 6 months, −0.88 mm (SD −0.20) after 12 months, −1.05 mm (SD −0.21) after 24 months, and −1.32 mm (SD −0.41) after 36 months.

Conclusions

Computer-guided surgery using double-template technique (DTT) shows a predictable outcome in the medium term, decreasing treatment timing and patient discomfort.



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People Who Value Virtue Show Wiser Reasoning

From romantic dramas to tensions at work, we're often better at working through other people's problems than our own—while we may approach our friends' problems with wise, clear-eyed objectivity, we often view our own problems through a personal, flawed, emotional lens.

But new research suggests that not everyone may struggle to reason wisely about their own personal problems. People who are motivated to develop the best in themselves and others don't show this bias—they tend to reason just as wisely about their own problems as they do for others.

The findings are published in Psychological Science, a journal of the Association for Psychological Science.

"Our findings suggest that people who value virtuous motives may be able to reason wisely for themselves, and overcome personal biases observed in previous research," explains psychological scientist Alex Huynh of the University of Waterloo. "This is in part due to their ability to recognize that their perspectives may not be enough to fully understand a situation, a concept referred to as intellectual humility."

Previous research has typically focused on how situations can affect a person's level of wise reasoning, but these findings suggest that personal motivations may also play a role.

"To our knowledge, this is the first research that empirically ties this conceptualization of virtue with wisdom, a connection that philosophers have been making for over two millennia," says Huynh. "These findings open up new avenues for future research to investigate how to increase a person's level of wisdom."

To explore the connection between personal ideals and reasoning, Huynh and University of Waterloo coauthors Harrison Oakes, Garrett R. Shay, and Ian McGregor recruited 267 university students to participate in this study.

The participants reported the extent to which they were motivated to pursue virtue by rating their agreement with statements like "I would like to contribute to others or the surrounding world" and "I would like to do what I believe in." Then, they were randomly assigned to think about either a personal conflict or a close friend's conflict, imagine that the conflict was still unresolved, and describe how they thought and felt about the situation. Finally, they rated how useful different wise reasoning strategies (e.g. searching for compromise, adopting an outsider's perspective) would be in addressing the conflict in question.

As expected, participants who thought about a friend's dilemma considered wiser strategies to be more useful than did the participants who thought about their own personal issues.

But the motivation to pursue virtue seemed to close this gap—participants who thought about personal problems rated wise-reasoning strategies as more valuable as their motivation to pursue virtue increased.

Further analyses revealed two specific components of wise reasoning that mattered most: considering other people's perspectives and intellectual humility. People who valued virtue may show wise reasoning because they recognize that understanding the full scope of their problem necessitates going beyond their personal perspective.

A second online study with 356 participants produced a similar pattern of results.

"Everyone is susceptible to becoming too invested in their own perspectives, but this doesn't have to be the case for everybody. As these findings suggest, your own personality and motivational orientation can influence your ability to approach your personal problems in a calmer, wiser manner," says Huynh.

Huynh and colleagues hope to test this relationship in additional experimental studies, examining whether training people to value virtuous motives—i.e., to focus on their personal ideals and contributing to others—boosts their ability to use wise reasoning strategies.

All data have been made publicly available and the design and analysis plan for Study 2 was preregistered via the Open Science Framework. The complete Open Practices Disclosure is available online. This article has received badges for Open Data and Preregistration.



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Brain signal intensity changes as biomarkers in amyotrophic lateral sclerosis

Objectives

To evaluate the contribution of the demographical, clinical, analytical and genetic factors to brain signal intensity changes in T2-weighted MR images in amyotrophic lateral sclerosis (ALS) patients and controls.

Methods

Susceptibility-weighted and FLAIR sequences were obtained in a 3T MR scanner. Iron-related hypointensities in the motor cortex (IRhMC) and hyperintensities of the corticospinal tract (HCT) were qualitatively scored. Age, gender, family history and clinical variables were recorded. Baseline levels of ferritin were measured. C9orf72 was tested in all patients and SOD1 only in familial ALS patients not carrying a C9orf72 expansion. Patients who carried a mutation were categorized as genetic. Associations of these variables with visual scores were assessed with multivariable analysis.

Results

A total of 102 ALS patients (92 non-genetic and 10 genetic) and 48 controls (28 ALS mimics and 20 healthy controls) were recruited. In controls, IRhMC associated with age, but HCT did not. In ALS patients, both HTC and IRhMC strongly associated with clinical UMN impairment and bulbar onset. The intensity/extent of IRhMC in the different motor homunculus regions (lower limbs, upper limbs and bulbar) were linked to the symptoms onset site. Between genetic and sporadic patients, no difference in IRhMC and HCT was found.

Conclusions

IRhMC and HCT are reliable markers of UMN degeneration in ALS patients and are more frequent in bulbar onset patients, independently of the mutation status. Age should be considered when evaluating IRhMC. The regional measurement of IRhMC following the motor homunculus could be used as a measure of disease progression.



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Combining olfactory test and motion analysis sensors in Parkinson's disease preclinical diagnosis: a pilot study

Objectives

Preclinical diagnosis of Parkinson's disease (PD) is nowadays a topic of interest as the neuropathological process could begin years before the appearance of motor symptoms. Several symptoms, among them hyposmia, could precede motor features in PD. In the preclinical phase of PD, a subclinical reduction in motor skills is highly likely. In this pilot study, we investigate a step-by-step method to achieve preclinical PD diagnosis.

Material and methods

We used the IOIT (Italian Olfactory Identification Test) to screen a population of healthy subjects. We identified 20 subjects with idiopathic hyposmia. Hyposmic subjects underwent an evaluation of motor skills, at baseline and after 1 year, using motion analysis sensors previously created by us.

Results

One subject showed significant worsening in motor measurements. In this subject, we further conducted a dopaminergic challenge test monitored with the same sensors and, finally, he underwent [123I]-FP/CIT (DaTscan) SPECT brain imaging. The results show that he is probably affected by preclinical PD.

Conclusions

Our pilot study suggests that the combined use of an olfactory test and motor sensors for motion analysis could be useful for a screening of healthy subjects to identify those at a high risk of developing PD.



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The death of Ben Hall

Abstract

Ben Hall was a nineteenth-century Australian bushranger (outlaw) who was shot and killed by colonial police on May 5 1865. Popular belief is that Hall was shot while sleeping in his camp bedding. This contrasts with the official police version of Hall being shot while attempting to escape by running away. To evaluate this divergence of opinion a study of the gun belt allegedly worn by Hall at the time of his fatal shooting was undertaken. This revealed a nineteenth-century belt with a defect corresponding to an oblique bullet hole. The shelving was in keeping with the shooter being located to the rear and left of the decedent, in a position corresponding to police reports. Scanning electron microscopy (SEM) revealed the presence of lead, in addition to mercury, silver and sulfur, materials used as primers in nineteenth century ammunition. Thus, contemporary examination of the belt provides support for the police version of events.



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Screening of Natural Bioactive Metabolites and Investigation of Antioxidant, Antimicrobial, Antihyperglycemic, Neuropharmacological, and Cytotoxicity Potentials of Litsea polyantha Juss. Ethanolic Root Extract

This study was designed to identify some bioactive phytochemicals from ethanolic extract of roots of Litsea polyantha and to evaluate some of its pharmacological activities. Phytochemical tests indicated the presence of reducing sugar, combined reducing sugar, tannins, flavonoids, alkaloids, terpenoids, and phenol. In the antioxidant assay using 2-diphenyl-1-picryl-hydrazyl (DPPH) free radical scavenging method, the IC50 value was found to be 82.31 μg/mL. Total content of phenolic compounds, flavonoid, and tannin was found to be 152.69 mg GAE/gm, 85.60 mg QE/gm, and 77.22 mg GAE/gm of dry extract, respectively. In disc diffusion antibacterial assay, the extract exhibited highest zone of inhibition up to 12.25 mm against Escherichia coli at the concentration of 500 μg/disc. For brine shrimp lethality bioassay, the extract exhibited LC50 56.082 μg/mL. In in vivo antihyperglycemic activity test by oral glucose tolerance test using Swiss Albino mice at the oral dose of 250 and 500 mg/kg, the extract showed statistically significant antihyperglycemic effect. Finally, in vivo, the extract exhibited the dose dependent CNS depressant effects by reducing the locomotors of Swiss Albino mice which was confirmed through three different neuropharmacological activity tests such as open field, hole cross, and hole board test.

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Chinese Herbal Medicine as an Adjunctive Therapy Ameliorated the Incidence of Chronic Hepatitis in Patients with Breast Cancer: A Nationwide Population-Based Cohort Study

We conducted a National Health Insurance Research Database-based Taiwanese nationwide population-based cohort study to evaluate whether Chinese herbal medicine (CHM) treatment decreased the incidence of chronic hepatitis in breast cancer patients receiving chemotherapy and/or radiotherapy. A total of 81171 patients were diagnosed with breast cancer within the defined study period. After randomly equal matching, data from 13856 patients were analyzed. Hazard ratios of incidence rate of chronic hepatitis were used to determine the influence and therapeutic potential of CHM in patients with breast cancer. The patients with breast cancer receiving CHM treatment exhibited a significantly decreased incidence rate of chronic hepatitis even across the stratification of age, CCI score, and treatments. The cumulative incidence of chronic hepatitis for a period of seven years after initial breast cancer diagnosis was also reduced in the patients receiving CHM treatment. The ten most commonly used single herbs and formulas were effective in protecting liver function in patients with breast cancer, where Hedyotis diffusa and Jia-Wei-Xiao-Yao-San were the most commonly used herbal agents. In conclusion, our study provided information that western medicine therapy combined with CHM as an adjuvant modality may have a significant impact on liver protection in patients with breast cancer.

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