Objectives/Hypothesis
Develop a patient-specific tissue engineered construct for laryngeal reconstruction following a partial laryngectomy.
Study Design
Bench and animal research.
Methods
A construct made from a porous polyethylene scaffold shaped in a canine-specific configuration and seeded with autologous canine adipose-derived stem cells in fibrin glue was implanted in a canine following a partial laryngectomy. After 1 year, the construct was first evaluated in vivo with high-speed imaging and acoustic–aerodynamic measures. It was then explanted and evaluated histologically.
Results
The canine study at 1 year revealed the construct provided voicing (barking) with acoustic and aerodynamic measures within normal ranges. The canine was able to eat and breathe normally without long-term support. The construct was integrated with epithelialization of all areas except the medial portion of the vocal fold structure. No anti-infective agents were needed after the standard perioperative medications were completed.
Conclusion
This study provided a successful first step toward developing a patient-specific composite construct for patients undergoing partial laryngectomies.
Level of Evidence
Not Applicable Laryngoscope, 2022
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