Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report.

Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report.:

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Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report.

Am J Case Rep. 2020 Jan 27;21:e917656

Authors: Dombrovsky I, Tilden HR, Aftandilians T, Wong S, Stowe RJ

Abstract

BACKGROUND Choriocarcinoma is the most aggressive form of gestational trophoblastic disease and usually occurs in women of childbearing age, most commonly within 1 year after an abnormal pregnancy. Postmenopausal choriocarcinoma is exceptionally rare and few cases have been described in the literature. CASE REPORT We present the case of a 66-year-old woman who presented to the Emergency Department with sudden onset of left upper- and lower-extremity weakness. She was found to have a brain mass, which was excised by neurosurgery and found to be a choriocarcinoma. She was then started on standard first-line therapy of EMACO, but was subsequently lost to follow-up. CONCLUSIONS Postmenopausal choriocarcinoma is rare and there are few case reports in the literature. It is a rare but possibly under-diagnosed metastatic disease in women. At present, a postmenopausal woman without a clear primary tumor should have a pregnancy test performed to rule out choriocarcinoma, as it is readily responsive to therapy.



PMID: 31986128 [PubMed - indexed for MEDLINE]