Voxel-based analysis for identification of urethro-vesical subregions predicting urinary toxicity after prostate cancer radiotherapy

Risk estimation of genitourinary (GU) toxicity after prostate radiotherapy is generally based on bladder dose-volume histograms (DVHs), disregarding any spatial dose-distribution information. We used a voxel-based approach to explore dosimetric regional differences in the bladder and the urethra associated with GU toxicity. The dose delivered to specific subregions of the urethra and the bladder was predictive of specific urinary symptoms, whereas the dose delivered to the whole bladder was less or not predictive.

http://bit.ly/2Be9RvJ