Commentary on “Sex differences in the effect of cannabinoid type 1 receptor deletion on locus coeruleus‐norepinephrine neurons and corticotropin releasing factor‐mediated responses”

Abstract

The recent study by Wyrofsky, Reyes, Yu, Kirby, and Van Bockstaele (2018) has provided important new evidence for sex‐driven modulation of endogenous cannabinoid (endocannabinoid) signalling during the stress response. It was reported in this study that cannabinoid receptor type 1 (Cnr1) deletion resulted in increased locus‐coeruleus norepinephrine excitability in male but not female mice. The study also reported increased norepinephrine, tyrosine hydroxylase and corticotrophin hormone levels in male but not female Cnr1 knockout mice (Wyrofsky et al., 2018).

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