Cefepime Pharmacokinetics in Critically Ill Pediatric Patients Receiving Continuous Renal Replacement Therapy [Pharmacology]

This retrospective study included pediatric intensive care unit patients receiving continuous venovenous hemodiafiltration (CVVHDF) being treated with cefepime. Free drug concentration time above one and four times a presumed MIC of 8 mcg/mL were calculated. Four patients received doses ranging from 48 to 64 mg/kg/dose every six to twelve hours. Three patients achieved 100% fT>1xMIC with the fourth achieving 98% fT>1xMIC. Therapeutic drug monitoring should be considered for critically ill patients receiving cefepime on CVVHDF.

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