A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation

How the immune system uses evolutionarily conserved signaling pathways involved in tissue development to orchestrate wound repair following injury has remained largely unresolved. Here, Minutti et al. show that the macrophage-derived EGFR ligand Amphiregulin induces local TGF-β activation and thereby the differentiation of tissue-resident pericytes.

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