Triclosan‐containing fluoride toothpaste on clinical parameters and osteo‐inflammatory mediators when applied in a stent during experimental peri‐implant mucositis in smokers

Abstract

Objectives

To determine the effect of triclosan‐containing fluoride toothpaste on the clinical parameters and the osteo‐immunoinflammatory mediators in the peri‐implant fluid when applied in a stent during experimental peri‐implant mucositis in smokers.

Materials and Methods

Twenty‐six smokers with an implant‐supported crown were enrolled in this double‐blind, randomized, crossover study. During the two 3‐week periods without mechanical toothbrushing (wash‐out period:30 days), patients were randomly assigned to: Triclosan/fluoride (n:13) or fluoride toothpaste (n:13), three times/day. Clinical and immunoenzymatic assays were performed at baseline, 3, 7, 14 and 21 days.

Results

Both groups showed increase in the plaque index throughout the study (p=0.001), without inter‐group differences at 21 days (p>0.05). No intra‐ or inter‐group differences were observed for IFN‐γ, IL10, IL‐1β, IL8, IL‐17, IL‐6, TNF‐α, MMP‐2, MMP‐9, TGF‐β, OC, OPN, ICTP, OPG and RANKL (p>0.05). However, the RANKL/OPG ratio was significantly higher in fluoride toothpaste‐treated sites when compared to triclosan/fluoride‐treated sites at the end of period without mechanical toothbrushing, on the 21^st day (p=0.041).

Conclusion

Triclosan‐containing toothpaste favorably modulated osteo‐immunoinflammatory mediators during the experimental peri‐implant mucositis in smokers, decreasing the ratio of RANKL/OPG.

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