The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation

Zhang et al. show that the BAF subunit Dpf2 and the PRC2 subunit Eed antagonistically regulate mesendodermal ESC differentiation by binding distinct Tbx3 enhancers. The PRC2 subunit Ezh2 also counteracts Dpf2 functions in differentiation but through a distinct mechanism involving Nanog repression, revealing that distinct BAF and PRC2 subunits control ESC differentiation.

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