Optimal therapeutic strategy using antigen‐containing liposomes selectively delivered to antigen‐presenting cells

Summary

Recent immunotherapies have demonstrated clinical success. In particular, vaccines based on particulate antigen (Ag) are expected to be implemented based on their efficacy. In the current study, we describe a strategy entailing Ag‐encapsulating poly(ethylene glycol)‐modified liposomes (PGL‐Ag) as antigen protein delivery devices and show that the success of the liposome depends on the antigen‐presenting cell (APC) capacity; after administration of PGL‐Ag, dendritic cells (DCs) in particular take up the Ag and subsequently prime T cells. For the generation of antitumor T cell responses in the lymphoid tissues, the function of encapsulated Ag‐capturing DCs in vivo could be a biomarker. We next designed a prime‐boost strategy to enhance the antitumor effects of the PGL‐Ag. In the tumor sites, we show that Ag retention in nanoparticle‐capturing DCs promotes a robust antitumor response. Thus, this efficient particulate Ag‐based host APC‐delivery strategy provides a bridge between innate and adaptive immune response and offers a novel therapeutic option against tumor cells.

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