Non-sinusoidal waveform in temperature-compensated circadian oscillations

Time series of biological rhythms are of various shapes. Here we investigated the waveforms of circadian rhythms in gene-protein dynamics, using newly developed index to quantify the degree of distortion from a sinusoidal waveform. In general, most biochemical reactions accelerate with increasing temperature, but the period of circadian rhythms remains relatively stable with temperature change, a phenomenon known as "temperature compensation". Despite extensive research, the mechanism underlying this remains unclear.

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