Nitric Oxide Therapy for Diabetic Wound Healing

Nitric oxide (NO)‐based therapies for chronic wound healing are explored in this progress report. The use of NO to accelerate wound healing is motivated by its role as an endogenous regulator of inflammation and antibacterial agent. A number of NO‐based wound healing strategies are developed, including those that liberate NO from endogenous reservoirs and those that dose exogenous NO.

Abstract

Nitric oxide (NO) represents a potential wound therapeutic agent due to its ability to regulate inflammation and eradicate bacterial infections. Two broad strategies exist to utilize NO for wound healing; liberating NO from endogenous reservoirs, and supplementing NO from exogenous sources. This progress report examines the efficacy of a variety of NO‐based methods to improve wound outcomes, with particular attention given to diabetes‐associated chronic wounds.

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