Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants

Children have a higher risk of developing asthma in low-LPS "clean" environments than adults. Bachus et al. demonstrate that infant mice require higher doses of LPS than adult mice to prevent Th2-dependent allergic responses because of the decreased ability to induce LPS-driven TNF-α production and TNFR-mediated CD11b+ dendritic cell activation for Th2 cell suppression.

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