EARLY‐ONSET CEREBRAL AMYLOID ANGIOPATHY FOLLOWING CHILDHOOD EXPOSURE TO CADAVERIC DURA

Abstract

Amyloid‐β transmission has been described in patients both with and without iatrogenic Creutzfeldt‐Jakob disease; however, there is little information regarding the impact of this acquired amyloid‐β pathology during life. Here, for the first time, we describe in detail the clinical and neuroimaging findings in three patients with early‐onset symptomatic amyloid‐β cerebral amyloid angiopathy following childhood exposure to cadaveric dura (by neurosurgical grafting in two patients, and tumour embolization in a third). Our observations provide further in vivo evidence that cerebral amyloid angiopathy might be caused by transmission of amyloid‐β seeds (prions) present in cadaveric dura, and has diagnostic relevance for younger patients presenting with suspected cerebral amyloid angiopathy.

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