A phase I pilot study of pre-operative radiotherapy for prostate cancer: Long-term toxicity and oncologic outcomes

We report the long-term results of a phase I pilot study assessing short-course pre-operative radiotherapy (PreORT) followed by radical prostatectomy in 15 unfavourable intermediate and high-risk prostate cancer (PCa) patients. With median follow-up of 12 years, the incidence of grade 2+ genitourinary and gastrointestinal toxicity were 53.3% and 6.7%, respectively. Biochemical and metastatic disease recurrence occurred in 53.3% and 40% of patients, respectively. Future studies must cautiously select PreORT technique and dose schedule.

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