Reply

We appreciate the opportunity to respond to the comments of Meyer et al concerning our recent publication on the relationship of patent ductus arteriosus (PDA) size and echocardiographic markers of PDA-related shunt volume. Contrary to our data, these investigators have shown an important correlation between acute kidney injury (AKI) and indexed PDA diameter.1 In their retrospective study of 422 very low birth weight infants (mean birth weight of 1059.0 ± 308.2 g) they demonstrated that AKI was associated with both clinical (birth weight, gestational age, Apgar score at 10 minutes, PDA surgery or the use of gentamicin) and echocardiography data (PDA size indexed to birth weight or PDA with compromised cerebral, mesenteric/celiac, or renal blood flow).

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