Fatal, paraparetic acute motor axonal neuropathy, early complicating chemotherapy with nab-paclitaxel

So far, very few cases describing an interrelation between chemotherapy and Guillain–Barré syndrome have been published. We describe the first case of a paraparetic, pure acute motor axonal neuropathy variant of Guillain–Barré syndrome, early complicating protein-bound paclitaxel (nab-paclitaxel/abraxane) chemotherapy (first and sole session at a 350 mg dose) in a female patient with metastatic breast cancer. Although our patient was treated with the standard regimen of intravenous immunoglobulin for 5 days, she showed no evidence of motor improvement and died 1 month after the onset of the neurological deficit. Correspondence to Andreas A. Argyriou, MD, PhD, Department of Neurology, Saint Andrews State General Hospital of Patras, 26335 Patras, Greece Tel/fax: +30 261 022 7969; e-mail: andargyriou@yahoo.gr Received October 4, 2018 Accepted December 6, 2018 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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