Danshen (Salvia miltiorrhiza Bunge), a natural powerful drug for various conditions treatment, has traditionally been used in Asian countries for centuries as anticancer agent, anti-inflammatory agent, and antioxidant. More recently, it is explored in combination with other herbs for skeletal diseases therapy; bone-targeting compounds with pharmacological activities have been isolated from various sources of traditional Chinese medicine (TCM), including Danshen. In this case, some evidence supports that Danshen may treat myelofibrosis (MF) by exerting its antitumor effect. To study the specific mechanism of Danshen in the treatment of MF, we used bioinformatics databases to determine its active ingredients. Then, identification of target proteins related to MF was made using a network pharmacology analysis platform. In our results, 20 key active compounds and 457 key targets of Danshen were identified. In-depth network analysis of the top diseases, functions, and pathways suggested that a common underlying mechanism linked Danshen involvement with MF. Finally, 5 potential targets were confirmed by the analysis; these 5 targets, as well as 20 previously identified compounds, were subjected to molecular docking experiments. The results indicated that cryptotanshinone of Danshen may affect MF by acting on the key genes in the JAK-STAT signalling pathway and the TGF-β signalling pathway.
https://ift.tt/2QeaRtj
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
▼
2018
(66471)
-
▼
Δεκεμβρίου
(5242)
-
▼
Δεκ 05
(243)
- Impact of Altered Airway Pressure on Intracranial ...
- Risk Factors for New-Onset Atrial Fibrillation in ...
- Current Sepsis Mandates Are Overly Prescriptive, a...
- ERBB2 mutation frequency in lobular breast cancer ...
- The Application of Blockchain Technology in Stroke...
- Pain therapy for the elderly patient: is opioid-fr...
- Correlation Analysis of MRI-based Graft Maturity a...
- Ultrasonographic assessment of carpal tunnel syndr...
- Response
- Strength reduction in unilateral shoulder pain: Is...
- Targeting of chondrocyte plasticity via connexin43...
- Variant of SNP rs1317082 at CCSlnc362 (RP11-362K14...
- Ferritin heavy subunit enhances apoptosis of non-s...
- Inactivation of Lon protease reveals a link betwee...
- UBIAD1 suppresses the proliferation of bladder car...
- Long noncoding RNA ATB promotes the epithelial−mes...
- LncRNA DANCR upregulates PI3K/AKT signaling throug...
- Mast cells are essential intermediaries in regulat...
- Cross-sectional and prospective follow-up study to...
- PRedicting Outcomes For Crohns dIsease using a moL...
- Opioid Use is Associated with Higher Severity-Adju...
- Re: “High Altitude and Cancer Mortality” by Thiers...
- Acute Mountain Sickness is Reduced Following 2 Day...
- Special focus issue: ‘innovations in diagnostic an...
- Applying virtual reality in forensics – a virtual ...
- A phase 1b dose-escalation and expansion study of ...
- A Very Oil Yellow1 Modifier of the Oil Yellow1-N19...
- Cell-based immunotherapy approaches for multiple m...
- A phase II study of tumor-infiltrating lymphocyte ...
- Eradication of central nervous system leukemia of ...
- Mitochondrial DNA in the tumour microenvironment a...
- FDA Warns of Rare Stroke Risk With Multiple Sclero...
- J-Shaped Association for Sleep Duration, CV Events...
- Type 2 Diabetes Linked to Colorectal Cancer Risk i...
- SABCS: Delaying Chemo Lowers Survival in Triple-Ne...
- Infections Linked to Increased Later Risk for Ment...
- Heterogeneity and Variability in Pressure Autoregu...
- Clinical Implications of the 2016 International St...
- Current status of esophageal endoscopy including t...
- Immunohistochemical characteristics of porcine int...
- Determination and classification of cutaneous inne...
- Stress-induced changes in the aged-rat adrenal cor...
- Variability of the vertebral artery origin and tra...
- Morphometric parameters and histological study of ...
- The superficial palmar branch of the radial artery...
- Anatomy of the feeding arteries of the cerebral ar...
- A possible association between medial depression o...
- Mandibular tori are associated with mandibular bon...
- Variations in carotid sinus anatomy and their rele...
- Coeliac trunk and common hepatic artery variations...
- Tensor fasciae latae muscle in human embryos and f...
- Variations of the cephalic vein anterior to the cl...
- Evaluation of localisation of mandibular foramen i...
- Common coeliacomesenteric trunk: a computed tomogr...
- Morphology of cranial sutures and radiologic evalu...
- The triticeous cartilage — redefining of morpholog...
- The posterior epidural ligament in the thoracic re...
- Autoimmune Thyroid Diseases
- Injectable Bulking Agent to Treat Postprostatectom...
- Integrated Analysis of MicroRNA (miRNA) and mRNA P...
- Automated, Noncontact Intraocular Pressure Home Mo...
- Molecular Cytogenetics of Pisum sativum L. Grown u...
- Adolescent social isolation affects parvalbumin ex...
- Reading the palm with MUNIX: A ‘reversed split han...
- Mitochondrial DNA in the tumour microenvironment a...
- Cell-based immunotherapy approaches for multiple m...
- Safety and efficacy of hot avulsion as an adjunct ...
- The clinicopathological analysis of receptor tyros...
- Spiritual Experiences of Adults with Advanced Canc...
- Difference in opinions about continuous deep sedat...
- Haplotypes of TNFα/β Genes Associated with Sex-Spe...
- Trends in Use of Electronic Health Records in Pedi...
- Delineation of the Individual Effects of Vitamin E...
- Reply
- Sedation Management for Critically Ill Children wi...
- https://ift.tt/2KXScfl
- Lessons to apply: Welfare check incident became a ...
- Multidisciplinary Assessment of Planning and Resec...
- Calif. ambulance company owner wins EMT of the Yea...
- History of Partner Violence Tied to Menopause Symp...
- Sympathetic nervous system as a target for aging a...
- Skin Autofluorescence Predicts T2DM, Heart Disease...
- Few Physicians Work in Practices That Use Telemedi...
- ASH: A+CHP Bests CHOP for Peripheral T-Cell Lymphoma
- Imaging, Biopsy Often Still Needed After Mastectomy
- Migraine With Aura Linked to Increase in Incident ...
- ASH: Rivaroxaban Prevents Blood Clots in At-Risk C...
- SABCS: T-DM1 Cuts Recurrent Invasive HER2+ Breast ...
- Self-Management Program Beneficial for Patients Wi...
- Machine Learning Models May Predict Emergency Admi...
- Cannabis‐based products for pediatric epilepsy: A ...
- Issue Information–ISSN page
- Epilepsia – December 2018 – Announcements
- 13th European Congress on Epileptology Vienna, 26–...
- Abstracts
- Author Index
- The Role of the Neo-Bioscore Staging System in Gui...
- Promising Long-Term Outcomes After Pelvic Exentera...
- ASO Author Reflections: Annexin A3 as a Potential ...
- ASO Author Reflections: PTTG1 Protein Expression i...
-
▼
Δεκ 05
(243)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
▼
Δεκεμβρίου
(5242)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Τετάρτη 5 Δεκεμβρίου 2018
Exploring the Mechanism of Danshen against Myelofibrosis by Network Pharmacology and Molecular Docking
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.