DANCR mediated miR‐665 regulates proliferation and metastasis of cervical cancer through ERK/SMADs pathway

Abstract

Emerging evidence has indicated that miRNAs play an important role in cervical cancer (CC). However, the role of miR‐665 in cervical cancer remains unclear. The aim of our present study was to investigate the potential functions of miR‐665 in CC and to identify the underlying mechanisms of action. In current study, we have shown that miR‐665 was down‐regulated in CC tissues and cell lines, which is negatively correlated with tumor size, distant metastasis, advanced TNM stage and poor prognosis. Functionally, miR‐665 inhibited cell proliferation, migration and invasion and the resistance for cis‐platinum of CC cells, as well as the tumor growth. We validated that TGFBR1 was a direct target of miR‐665 and mediated the ERK/SMADs pathway. In addition, we identified miR‐665 as the ceRNA for lnc‐DANCR. These observations suggested that lnc‐DANCR mediated miR‐665 downregulation regulates the malignant phenotype of CC cells by targeting TGFBR1 through the ERK/SMADs pathway, which may present a path to novel therapeutic stratagems for the CC therapy.

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