Quantitative Clonal Analysis and Single-Cell Transcriptomics Reveal Division Kinetics, Hierarchy, and Fate of Oral Epithelial Progenitor Cells

Jones et al. define the organization, cycling kinetics, and clonal dynamics of oral mucosal progenitor cells. They also show, via single-cell RNA sequencing, that the basal layer contains progenitor and post-mitotic cells at various stages of maturation, demonstrating basal layer heterogeneity and providing insights into localization of cell fate decisions.

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