Notch-Induced miR-708 Antagonizes Satellite Cell Migration and Maintains Quiescence

Baghdadi et al. show that Notch signaling induces transcription of the quiescence-specific mirtron miR-708 that represses Tensin3, a component of the focal adhesion complex. This repression inhibits FAK activation, which in turn stabilizes satellite cells within their niche. miR-708 regulates quiescence and self-renewal by active repression of cell migration.

https://ift.tt/2Feg0wd